Milwood, Michigan, is home to a wide variety of streets, aeas, and districts, each with its own unique character and charm. The most notable areas within and around Milwood include the prestigious Golden Triangle (the area between Portage Street and Lovers Lane with homes mostly over $300,000), Portage Street corridor, Lovers Lane, Cork Street district, Homecrest Avenue, Cambridge Drive, Kingston area, and Monarch Street. Additional areas encompass the Kalamazoo/Battle Creek International Airport vicinity, Milham Park Golf Course area, Vanderberg Park (named for longtime Little League coordinator Harold 'Bud' Vanderberg), Milwood Elementary School district, and the Wings Event Center zone.

The neighborhood features various subdivisions and residential streets including those near the historic Cork Lane Shopping Center (Kalamazoo's original strip mall), the One Well Brewing district, areas around major employers like Fabri-Kal, Schupan & Sons, Imperial Beverage, Continental Linen Supply, MDOT Southwest Michigan Regional offices, Consumers Energy Regional Operations facility, Kalamazoo County Road Commission, Pepsi Regional Bottling & Operations, and Zoetis Division facilities. Religious and community areas include locations around Milwood Christian Reformed, Greenwood Reformed, Covenant United Reformed, Bethlehem Baptist, and Milwood United Methodist churches.

Additional areas within the 4.8 square mile neighborhood include the northern sections developed in the early 20th century, post-World War II developments near Kilgore Road, areas near the former Kalamazoo Paper Company site, historic Portage Creek areas, and residential zones with Cape Cod, Colonial, and mid-century Ranch architectural styles. The neighborhood also encompasses zones near Portage Creek Bicentennial Park, areas connecting to nearby neighborhoods like Edison, Eastside, Vine, Westwood, and Eastwood, as well as sections with zip codes 49001, 49002, 49009, 49015, 49024, 49071, and 49083. Together, these areas create a rich and diverse community that defines Milwood's unique identity as the largest neighborhood by area in Kalamazoo, ranging from the luxury Golden Triangle homes and airport-adjacent commercial districts to family-friendly residential streets, historic areas, recreational facilities, and industrial zones that collectively offer residents everything they could want without leaving the neighborhood.